Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

It is demonstrate06d that the convenient preparation of PAA-PNIPAm hydrogel capsules were fabricated by a templated strategy in aqueous solution. It is noteworthy that PNIPAm belongs to thermoresponsive polymers, so the PAA-PNIPAm hydrogel capsules serving as drug carriers are expected to exhibit a thermo controlled-released character. Hydrophilic antitumor drug Dox was successfully entrapped in these hydrogel capsules based on charge controlled permeability mechanism, leading to a new high loading capacity of 280 % to the weight of the carriers. More encouragingly, the release of drug from the PAA-PNIPAm hydrogel capsules exhibited a slowrate but sustainable feature, and behaved the thermo and pH dual-responsivity. In vitro cytotoxicity assay indicated that the Dox-loaded PAA-PNIPAm hydrogel capsules have high antitumor activity. Considering the simple and mild preparation procedure, high drug loading capacity as well as the desired dual-responsive controlled release property, the PAA-PNIPAm hydrogel capsules may serve as a promising candidate for intelligent drug delivery system. These results firmly confirmed that the PAA-PNIPAm hydrogel capsules as a drug carrier had an excellent biosecurity and a high pharmacological activity.

Original article citation

Jingya Nan, Ying Chen, Rutian Li, Jifu Wang, Meihong Liu, Chunpeng Wang and Fuxiang Chu,“Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release”, Nano-Micro Lett. 6(3), 200-208 (2014).  http://dx.doi.org/10.5101/nml140022a

A Highlight from Mengjun Shu for NMSTR.

 

 

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