A New Approach for Producing Polymer Nanoparticles

A New Approach for Producing Polymer Nanoparticles

012Ge et al. developed a new type of protein-polymer hybrid nanoparticles made of hydrophilic denatured bovine serum albumin (BSA) covalently bonded to hydrophobic poly(methyl methacrylate) (PMMA).

The nanoparticles were loadedwith the anti-tumor drug camptothecin. With albumin serving as a nutrient to cells, the drug-encapsulated nanoparticle shows an enhanced ability to kill cancer cells compared to that of the free drug in solution both in vitro and in vivo.

They have demonstrated that the hybrid nanoparticles prepared by precipitating in SC-CO2 have excellent biocompatibility and efficient cell uptake. The preparation process is simple and easy to scale up. As an example of this type of drug delivery vehicles, compared with free drug formulation, the camptothecin-encapsulated BSA-PMMA nanoparticles shows enhanced anti-tumor activity both in vitro and in animals.

Original article citation

Maofang Hua and Xiufu Hua, “Polymer Nanoparticles Prepared by Supercritical Carbon Dioxide for in Vivo Anti-cancer Drug Delivery”, Nano-Micro Lett. 6(1), 20-23 (2014). http://dx.doi.org/10.5101/nml.v6i1.p20-23

A Highlight from Weidong Zhang for NMSTR.

 

 

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